Endocrine Abstracts

Introduction: Thyroidal status can play important role in progression mammary gland tumour growth. We have already shown that hypothyroidism induced by application of 6-n-propylthiouracil (PTU) – inhibitor of type I iodothyronine 5′-deiodinase (5′-DI) – prolonged tumour latency and reduced number, volume and burden of 1-methyl-1-nitrosourea (MNU) induced rat mammary gland tumours in Sprague–Dawley female rats.1<p class="abstex...

1-methyl-1-nitrosourea (MNU) is a well characterized carcinogen that induces adenocarcinomas in rat mammary gland with high specifity. This model has proven to be of resemblance to human breast cancer. Synthetic analogs of vitamin D3 and retinoids have shown some promise as chemopreventive agents against chemically induced mammary gland carcinogenesis in rodents.Female Sprague-Dawley rats were given 50 mg/kg MNU i.p. on 46th and 52nd day of ag...

Retinoid receptors (RARs) upon a proper ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as heterodimers with retinoid X receptors (RXRs). Predominantly, novel synthetic retinoid analogues acting through RARs as redifferentiation agents would be of great value in treating patients with advanced thyroid cancer.The objective of this study was to investigate all-trans retinoic acid/9-cis retinoic acid n...